Synthesis and Biological Evaluation of 2-Mercaptobenzimidazole Derivatives as Anti-inflammatory Agents
Saumya Gupta,
Surya Prakash Gupta,
Neeraj Upmanyu,
Gopal Garg
Issue:
Volume 1, Issue 2, December 2015
Pages:
12-16
Received:
9 November 2015
Accepted:
23 December 2015
Published:
25 December 2015
DOI:
10.11648/j.jddmc.20150102.11
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Abstract: A series of 2-mercaptobenzimidazole derivatives (MB1–MB5) were synthesized by mannich reaction. The purity of synthesized compounds were determined by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The newly synthesized compounds were screened for anti-inflammatory activities on carrageenan induced paw oedema in rats. Compounds MB1 and MB5 showed a significant anti-inflammatory activity when compared with standard drug indomethacin. The other compounds showed promising anti-inflammatory activity.
Abstract: A series of 2-mercaptobenzimidazole derivatives (MB1–MB5) were synthesized by mannich reaction. The purity of synthesized compounds were determined by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The newly synthesized compounds were screened for anti-inflammatory a...
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Antimicrobial Potential of Glycyrrhiza glabra
Asad Abbas,
Muhammad Zubair,
Nasir Rasool,
Komal Rizwan
Issue:
Volume 1, Issue 2, December 2015
Pages:
17-20
Received:
14 November 2015
Accepted:
9 December 2015
Published:
4 January 2016
DOI:
10.11648/j.jddmc.20150102.12
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Abstract: This study was carried out to evaluate the antimicrobial activity of methanolic extract and different fractions (n-butanol, ethyl acetate, chloroform and n-hexane) of Glycyrrhiza glabra root. The antimicrobial activity was determined by the disc diffusion method and minimum inhibitory concentration (MIC) against a panel of microorganisms (four bacterial strains, i.e P. multocida, E. coli, B. subtilis and S. aureus and three fungal strains, i.e. A. flavus, A. niger and R. solani). The results indicated that plant extract and fractions mildly potent as antimicrobial agent.
Abstract: This study was carried out to evaluate the antimicrobial activity of methanolic extract and different fractions (n-butanol, ethyl acetate, chloroform and n-hexane) of Glycyrrhiza glabra root. The antimicrobial activity was determined by the disc diffusion method and minimum inhibitory concentration (MIC) against a panel of microorganisms (four bact...
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