Review Article
A Review of Current Trends and Advances in Analytical Methods for Determination of ACE Inhibitors Combinations with Hydrochlorothiazide
Issue:
Volume 11, Issue 2, June 2025
Pages:
13-30
Received:
31 January 2025
Accepted:
28 February 2025
Published:
24 May 2025
Abstract: Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combination therapies, there is a growing demand for analytical methods that can accurately, precisely, and cost-effectively assess these complex formulations. Objective. This review examines the various analytical methods used to analyze ACE inhibitor combinations with hydrochlorothiazide, focusing on studies published between 1990 and 2024. The methods are critically evaluated, compared, and assessed for their practical applicability. Results. A review of the literature revealed that different analytical techniques have been employed for the determination of ACE inhibitor–hydrochlorothiazide combinations. Recent trends indicate a preference for HPLC (48.7%), spectrophotometric methods (23.1%), thin-layer chromatography (TLC) (15.4%), capillary electrophoresis (7.7%), and Fourier transform infrared (FTIR) spectroscopy (5.1%). Conclusion and main ideas. HPLC remains the gold standard for the analysis of ACE inhibitor–hydrochlorothiazide combinations. However, alternative methods like spectrophotometry and TLC provide viable options for simpler and cost-effective analysis The selection of an appropriate analytical technique should align with analytical goals, regulatory compliance, and available resources. Future research may focus on advancing rapid and environmentally friendly analytical techniques.
Abstract: Background. Hypertension is a leading risk factor for cardiovascular diseases, contributing significantly to global morbidity and mortality. Combination therapy using an angiotensin-converting enzyme (ACE) inhibitor with a diuretic offers distinct advantages over monotherapy in managing hypertension. With the increasing use of fixed-dose combinatio...
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Sayda Mohamed Osman
