Grape seed polyphenols (GPP) have been known to have various pharmaceutical activities including anti-oxidant and anti-tumor activity. However, its clinical application is hindered by low stability and bioavailability. One of the most common methods for solving these problems is to use different types of carriers. Recently, protein based drug delivery system has gained a great interest. In this study, bovine serum albumin (BSA) nanoparticles loaded GPP were manufactured by desolvation method. Several characteristics such as the average size, shape, releasing behavior and stability under UV light were tested by different techniques. Anti-oxidant activity of BSA-GPP nanoparticles were compared to free GPP. In addition, anti-tumor activity was also studied in mice model injected sarcoma-180 cells. The result showed that the shape of prepared BSA-GPP nanoparticles was spherical with the average size of 207.02nm. GPP were released by a diffusion from the nanoparticles. The nanoparticles loaded GPP showed relatively higher stability under UV condition. BSA-GPP nanoparticles maintained longer in vitro antioxidant activity than free GPP. Importantly, tumor inhibition rate of BSA-GPP nanoparticles was 84%, which was much higher than that of free GPP. In summary, BSA nanoparticles had a high potential to be used as a carrier for improving stability and increasing bioavailability of GPP.
| Published in | Journal of Drug Design and Medicinal Chemistry (Volume 11, Issue 4) |
| DOI | 10.11648/j.jddmc.20251104.11 |
| Page(s) | 55-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Grape Seed Polyphenols, Bovine Serum Albumin, Nanoparticles, Bioavailability, Stability
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APA Style
Rim, S., Jang, S., Rim, G., An, C., To, K. (2025). Investigation into the Anti-oxidant and Anti-Tumor Activity of the Bovine Serum Albumin Nanoparticles Containing Grape Seed Polyphenols Fabricated by Desolvation Method. Journal of Drug Design and Medicinal Chemistry, 11(4), 55-62. https://doi.org/10.11648/j.jddmc.20251104.11
ACS Style
Rim, S.; Jang, S.; Rim, G.; An, C.; To, K. Investigation into the Anti-oxidant and Anti-Tumor Activity of the Bovine Serum Albumin Nanoparticles Containing Grape Seed Polyphenols Fabricated by Desolvation Method. J. Drug Des. Med. Chem. 2025, 11(4), 55-62. doi: 10.11648/j.jddmc.20251104.11
AMA Style
Rim S, Jang S, Rim G, An C, To K. Investigation into the Anti-oxidant and Anti-Tumor Activity of the Bovine Serum Albumin Nanoparticles Containing Grape Seed Polyphenols Fabricated by Desolvation Method. J Drug Des Med Chem. 2025;11(4):55-62. doi: 10.11648/j.jddmc.20251104.11
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Download@article{10.11648/j.jddmc.20251104.11,
author = {Su-Chol Rim and Su-Ung Jang and Gyong-Man Rim and Chol An and Kwang-Il To},
title = {Investigation into the Anti-oxidant and Anti-Tumor Activity of the Bovine Serum Albumin Nanoparticles Containing Grape Seed Polyphenols Fabricated by Desolvation Method},
journal = {Journal of Drug Design and Medicinal Chemistry},
volume = {11},
number = {4},
pages = {55-62},
doi = {10.11648/j.jddmc.20251104.11},
url = {https://doi.org/10.11648/j.jddmc.20251104.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20251104.11},
abstract = {Grape seed polyphenols (GPP) have been known to have various pharmaceutical activities including anti-oxidant and anti-tumor activity. However, its clinical application is hindered by low stability and bioavailability. One of the most common methods for solving these problems is to use different types of carriers. Recently, protein based drug delivery system has gained a great interest. In this study, bovine serum albumin (BSA) nanoparticles loaded GPP were manufactured by desolvation method. Several characteristics such as the average size, shape, releasing behavior and stability under UV light were tested by different techniques. Anti-oxidant activity of BSA-GPP nanoparticles were compared to free GPP. In addition, anti-tumor activity was also studied in mice model injected sarcoma-180 cells. The result showed that the shape of prepared BSA-GPP nanoparticles was spherical with the average size of 207.02nm. GPP were released by a diffusion from the nanoparticles. The nanoparticles loaded GPP showed relatively higher stability under UV condition. BSA-GPP nanoparticles maintained longer in vitro antioxidant activity than free GPP. Importantly, tumor inhibition rate of BSA-GPP nanoparticles was 84%, which was much higher than that of free GPP. In summary, BSA nanoparticles had a high potential to be used as a carrier for improving stability and increasing bioavailability of GPP.},
year = {2025}
}
TY - JOUR T1 - Investigation into the Anti-oxidant and Anti-Tumor Activity of the Bovine Serum Albumin Nanoparticles Containing Grape Seed Polyphenols Fabricated by Desolvation Method AU - Su-Chol Rim AU - Su-Ung Jang AU - Gyong-Man Rim AU - Chol An AU - Kwang-Il To Y1 - 2025/12/24 PY - 2025 N1 - https://doi.org/10.11648/j.jddmc.20251104.11 DO - 10.11648/j.jddmc.20251104.11 T2 - Journal of Drug Design and Medicinal Chemistry JF - Journal of Drug Design and Medicinal Chemistry JO - Journal of Drug Design and Medicinal Chemistry SP - 55 EP - 62 PB - Science Publishing Group SN - 2472-3576 UR - https://doi.org/10.11648/j.jddmc.20251104.11 AB - Grape seed polyphenols (GPP) have been known to have various pharmaceutical activities including anti-oxidant and anti-tumor activity. However, its clinical application is hindered by low stability and bioavailability. One of the most common methods for solving these problems is to use different types of carriers. Recently, protein based drug delivery system has gained a great interest. In this study, bovine serum albumin (BSA) nanoparticles loaded GPP were manufactured by desolvation method. Several characteristics such as the average size, shape, releasing behavior and stability under UV light were tested by different techniques. Anti-oxidant activity of BSA-GPP nanoparticles were compared to free GPP. In addition, anti-tumor activity was also studied in mice model injected sarcoma-180 cells. The result showed that the shape of prepared BSA-GPP nanoparticles was spherical with the average size of 207.02nm. GPP were released by a diffusion from the nanoparticles. The nanoparticles loaded GPP showed relatively higher stability under UV condition. BSA-GPP nanoparticles maintained longer in vitro antioxidant activity than free GPP. Importantly, tumor inhibition rate of BSA-GPP nanoparticles was 84%, which was much higher than that of free GPP. In summary, BSA nanoparticles had a high potential to be used as a carrier for improving stability and increasing bioavailability of GPP. VL - 11 IS - 4 ER -
Department of Nanomaterials, University of Sciences, Pyongyang, DPR Korea
