Volume 5, Issue 2, June 2019, Page: 18-25
Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug
Meghdad Payab, Department of Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran
Mohammad Javad Chaichi, Department of Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran
Ome Leila Nazari, Department of Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran
Fatemeh Yousefnejad Maleki, Department of Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran
Received: May 29, 2019;       Accepted: Jul. 10, 2019;       Published: Aug. 6, 2019
DOI: 10.11648/j.jddmc.20190502.11      View  22      Downloads  9
Abstract
In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.
Keywords
Tannin, Oak Gall, Deferral, Iron chelation, Thalassemia
To cite this article
Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki, Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug, Journal of Drug Design and Medicinal Chemistry. Vol. 5, No. 2, 2019, pp. 18-25. doi: 10.11648/j.jddmc.20190502.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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