Volume 3, Issue 3, June 2017, Page: 32-36
Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats
Johnson Olaleye Oladele, Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Olu Israel Oyewole, Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Olamilekan Kabiru Bello, Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria
Oluwaseun Titilope Oladele, Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Received: Apr. 6, 2017;       Accepted: Apr. 21, 2017;       Published: Jul. 4, 2017
DOI: 10.11648/j.jddmc.20170303.11      View  2142      Downloads  123
Abstract
Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (P<0.05) in activities of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Acid phosphatase (ACP) and alkaline phosphatase (ALP). Lipid peroxidation was induced as shown by significant increase (P<0.05) in malondialdehyde (MDA) level and induction of oxidative stress with significant decrease (P<0.05) in reduced glutathione (GSH), Glutathione S-transferase (GST), Superoxide dismutase (SOD), Catalase (CAT) levels. Histological study of the liver shows loss of normal architecture, small-sized cytoplasmic vacuole, cellular degeneration and necrosis. However, concomitant administration of aqueous extract of Telfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.
Keywords
Hepatotoxicity, Lipid Peroxidation, Oxidative Stress, Cadmium Chloride, Telfairia occidentalis
To cite this article
Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele, Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats, Journal of Drug Design and Medicinal Chemistry. Vol. 3, No. 3, 2017, pp. 32-36. doi: 10.11648/j.jddmc.20170303.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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