Journal of Drug Design and Medicinal Chemistry

Volume 5, Issue 3, September 2019

  • New ACE Inhibitor Designed from Nicotianamine and Its Docking Pose Prediction Using the Gold Program

    Noboru Takada, Takaharu Okada, Eri Kogawa, Yohsuke Sanada, Ayumi Ishidoya

    Issue: Volume 5, Issue 3, September 2019
    Pages: 33-39
    Received: Jul. 16, 2019
    Accepted: Aug. 07, 2019
    Published: Aug. 23, 2019
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    Abstract: Hypertension is currently one of the most serious health issues worldwide. Nicotianamine, a non-peptide-type amino acid trimer, is ubiquitously present in higher plants and plays a role as an internal metal transporter. It is known that nicotianamine inhibits ACE activity and that oral treatment with the compound improves hypertension. However the ... Show More
  • Rational Computational Study for New Kinase Inhibitors

    Joao Eustaquio Antunes, Michelle Bueno de Moura Pereira

    Issue: Volume 5, Issue 3, September 2019
    Pages: 40-46
    Received: Jun. 25, 2019
    Accepted: Aug. 06, 2019
    Published: Sep. 02, 2019
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    This article belongs to the Special Issue Drug Discovery of New Kinases Inhibitors
    Abstract: The development of new drugs can present several problems, it is a important obstacle the ability to adapt a molecule that is a potent pharmacological inhibitor and that is also possible to execute its synthesis. Quinazolines are known to be capable of inhibiting kinases. Thus, a detailed study was carried out to propose new quinazolines with alrea... Show More