Journal of Drug Design and Medicinal Chemistry

Volume 5, Issue 1, March 2019

  • Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies

    Imene Chetoui, Safa Bejaoui, Chaima Fouzai, Wafa Trabelsi, Salwa Nechi, Emna Chelbi, Mohamed Ghalghaf, M’hamed El Cafsi, Nejla Soudani

    Issue: Volume 5, Issue 1, March 2019
    Pages: 1-9
    Received: Mar. 12, 2019
    Accepted: Apr. 27, 2019
    Published: Jun. 12, 2019
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    Abstract: Lead is non-essential toxic metal used in the industrial process causes severe risk to aquatic organisms. This study aimed (aims) to evaluate the effect of Pb on oxidative stress in gills of Mactra corallina. During the experiment, bivalves were randomly divided into four groups, control served as control and D1, D2 and D3 groups were exposed to Pb... Show More
  • Investigation of Toxicity and Systemic Exposure of Bioactive Compounds of Aqueous Leaf Extract of Azadirachta indica A. Juss (Meliaceae) on Wistar Rats

    Tembe Fokunang Estella, Ndi Sirri Akwen, Njinkio Borgia Nono, Tsabang Nole, Ndikum Valentin Nchafor, Ngameni Bathelemy, Nguefack Tsague Georges, Charles Fokunang, Ngadjui Bonaventure Tchaleu

    Issue: Volume 5, Issue 1, March 2019
    Pages: 10-17
    Received: Apr. 26, 2019
    Accepted: May 28, 2019
    Published: Jun. 24, 2019
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    Abstract: Conventional medications used to treat ulcers are not easily accessible to remote areas, costly and not without side effects, thus causing many patients residing in rural areas to resort to herbal means of treatment. World Health Organization records that at least 80% of the world’s population depends on herbal medicinal products. Herbal therapy is... Show More