Journal of Drug Design and Medicinal Chemistry

Volume 4, Issue 3, September 2018

  • Exploration of Novel Sulpho Tyrosine Based Unnatural Amino Acid Ligand for Inhibition of Human Shp2; A Computational Approach

    Rajaganapathy Kaliyaperumal, Manjunatha Panduranga Mudugal, Prashantha Nagaraja, Nageena Taj

    Issue: Volume 4, Issue 3, September 2018
    Pages: 22-34
    Received: Sep. 24, 2018
    Accepted: Oct. 08, 2018
    Published: Nov. 05, 2018
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    Abstract: The SHP2 protein is a Protein tyrosine phosphates (PTPs) protein family, it catalyze the dephosphorylation of phosphotyrosine residues in protein substrates and play a critical roles in regulating intracellular signal transduction and is responsible for controlling cell growth, differentiation, motility, and metabolism. Whereas, Shp2 has non-recept... Show More