Journal of Drug Design and Medicinal Chemistry

Volume 3, Issue 6, December 2017

  • Naproxen-Gelucire Nanoformulations for Improved Solubility and Dissolution Rate of Poorly Water-Soluble Drug Naproxen

    Sandeep Patnaik, Aditya Dileep Kurdekar, Lakshmi Adinarayana Avinash Chunduri, Chinnakoti Prathibha, Kamisetti Venkataramaniah

    Issue: Volume 3, Issue 6, December 2017
    Pages: 77-85
    Received: Jun. 23, 2017
    Accepted: Oct. 25, 2017
    Published: Nov. 23, 2017
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    Abstract: Naproxen-Gelucire Nanoformulations (NFs) in terms of their phase solubility behavior, physico-chemical characteristics, cytotoxicity and morphology and dissolution enhancement has been studied using the poorly water soluble drug, naproxen. The NFs were prepared via wet milling using a conventional Retsch Planetary ball mill in various ratios of dru... Show More
  • In silico Design of Phosphonic Arginine and Hydroxamic Acid Inhibitors of Plasmodium falciparum M17 Leucyl Aminopeptidase with Favorable Pharmacokinetic Profile

    Hermann N'Guessan, Eugene Megnassan

    Issue: Volume 3, Issue 6, December 2017
    Pages: 86-113
    Received: Nov. 17, 2017
    Accepted: Dec. 08, 2017
    Published: Jan. 11, 2018
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    Abstract: We virtually design here new subnanomolar range antimalarials, inhibitors of plasmodium falciparum M17 Aminopeptidase (pfA-M17), by means of structure-based molecular design. Complexation QSAR models were elaborated for two training sets (6 methylphosphonic acids (APP) resp. 13 Hydroxamic Acid derivatives (AHO): QSARAPP. resp. QSARAHO) and a linear... Show More